In-class reading, assigned reading for homework, and research.
Students often lost their handouts/books and it was hard to tell who was actually doing their reading.
I often assign annotations to make sure students are reading thoroughly.
First, it ensures that students have their reading. No one can forget/lose their reading; as long as they have internet access, they can do their reading. Embedded questions help keeps students engaged throughout the text. It also helps me reinforce certain ideas by asking a question in the moment (instead of having to wait until the student has finished the text). The ability to alter font & color (as well as the font for people with dyslexia) also helps to keep students engaged. I also appreciate the ability to insert notes and media to enhance understanding. Finally, I love the meta-data: I can see how long it took a student to read, how many words they looked up, what areas confused them, etc. I get a much fuller picture of each student's comprehension.
I mostly assign short fiction and nonfiction. I still really value paper books, so I've yet to use Actively Learn for any of our longer texts. I like the ability to ask different questions. Using the multiple choice allows me to assess the students' understanding without actually having to sit down and do the grading. Of course, the ability to ask short answer questions allows me to probe deeper understanding (and allowing students to see their classmates responses after they answer a question allows for instant feedback even for longer questions). Finally, I've tried more creative uses of the program. For instance, instead of assigning questions, I'll sometimes assign annotations (asking students to leave a certain number of notes).
Start small. Use a small text with some well-worded short answer questions. Encourage students to take advantage of everything the program has to offer (looking up definitions, marking areas they don't understand, taking notes, etc.).